The '50s: apple pie, Andy Griffith, and MK Ultra

Project MKULTRA, or MK-ULTRA, was the code name for a covert CIA human research program, run by the CIA's Office of Scientific Intelligence. This official U.S. government program began in the early 1950s, continuing at least through the late 1960s, and it used U.S. and Canadian citizens as its test subjects.[1][2][3][4]

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The CIA was fascinated by LSD, and thought it a wonder drug that could be used not only to create zombie-like armies, but to drive enemy leaders like Fidel Castro insane. There were few willing subjects in the research — often, LSD was secretly given to a range of people, from CIA employees to prostitutes and the mentally ill. Sometimes, agents even posed as prostitutes and secretly drugged their clients, while fellow agents watched in two-way mirrors.

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"That was in the past. We've found Jesus!" - CIA